Chen X, Lin E, Haghightatian M.M, Shepard L.W., Hatter S, Kuruvilla R, & Zhao H. Light modulates glucose and lipid homeostasis via the sympathetic nervous system. Sci Adv 2024 Dec 11;10(50):eadp3284. PDF

Kumari R, Pascalau R, Wang H, Bajpayi S, Yurgel M, Quansah K, Hattar S, Tampakakis E, Kuruvilla R. Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice. Cell Reports 2024 Feb 27;43(2):113674. PDF

Connor, B.M., Moya-Alvarado, G, Yamashita, Y, and Kuruvilla, R. Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function. PNAS 2023 Feb 7;120(6). PDF

Mapps, A.A., Boehm,E., Beier, C., Keenan, W.T., Langel, J., Liu,M., Hattar, S., Zhao, H., Tampakakis, E., and Kuruvilla, R. Satellite glia modulate sympathetic neuron survival, activity, and autonomic function. eLife. 2022 Aug 23;11:e74295.doi: 10.7554/eLife.74295. PDF

Mapps A.A., Thomsen M.B., Boehm E, Zhao H, Hattar S, and Kuruvilla R. Diversity of satellite glia in sympathetic and sensory ganglia. Cell Reports 2022 Feb 1;38(5):110328. PDF

Emily Scott-Solomon, Erica Boehm, and Rejji Kuruvilla. The sympathetic nervous system in development and disease. Nature Reviews Neuroscience. Oct 2021. PDF

Eugene Lin, Emily Scott-Solomon, and Rejji Kuruvilla. Peripheral innervation in the regulation of glucose homeostasis. Trends in Neurosciences. 2020 Nov 20:S0166-2236(20)30248-4. PDF

Raluca Pascalau Rejji Kuruvilla. A Hairy End to a Chilling Event. Cell 2020 Aug 6;182(3):539-541. PDF

Douglass SM, Fane ME, Sanseviero E, Ecker BL, Kugel CH, Behera R, Kumar V, Tcyganov EN, Yin X, Liu Q, Chhabra Y, Alicea GM, Kuruvilla R, Gabrilovich DI, Weeraratna AT. Myeloid-derived suppressor cells are a major source of Wnt5A in the melanoma microenvironment and depend on Wnt5A for full suppressive activity. Cancer Res. 2020 Dec 1. PDF

Avraham O, Deng P-Y, Jones S, Kuruvilla R, Semenkovich C.F., Klyachko V.A., Cavalli V. Satellite glial cells promote regenerative growth in sensory neurons. Nature. Commun 2020 Sep 29;11(1):4891. PDF

Emily Scott-Solomon and Rejji Kuruvilla. Prenylation of Axonally Translated Rac1 Controls NGF-Dependent Axon Growth. Developmental Cell. 2020 Jun 2:S1534-5807(20)30409-3. PDF

Rejji Kuruvilla. Why brown fat has a lot of nerve. Nature. 2019 May;569(7755):196-197. News and Views. PDF

Alexis Ceasrine, Nelmari Ruiz-Otero , Eugene Lin, David Lumelsky, Erica Boehm, and Rejji Kuruvilla. Tamoxifen Improves Glucose Tolerance in a Delivery-, Sex-, and Strain-Dependent Manner in Mice. Endocrinology. 2019 Apr 1;160(4):782-790. PDF

Hamish Crerar#, Emily Scott-Solomon#, Chantal Bodkin-Clarke#, Catia Andreassi, Maria Hazbon, Emilie Logie, Marife Cano-Jaimez, Marco Gaspari, Rejji Kuruvilla*, Antonella Riccio*. Regulation of NGF Signaling by an Axonal Untranslated mRNA. Neuron. 2019 Feb 27. pii: S0896-6273(19)30120-5. PDF
#co-first authors, *co-corresponding authors.

Alexis Ceasrine, Eugene Lin, David Lumelsky, Radhika Iyer, and Rejji Kuruvilla. Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature. Elife. 2018 Oct 10;7. pii: e39689. PDF

Naoya Yamashita, Rajshri Joshi, Sheng Zhang, Zhong-Yin Zhang, and Rejji Kuruvilla. Phospho-regulation of soma-to-axon transcytosis of neurotrophin receptors. Developmental Cell. 2017 Sep 25;42(6):626-639. PDF

Chih-Ming Chen, Lauren Orefice, Shu-Ling Chiu, Tara LeGates, Samer Hattar, Richard Huganir, Haiqing Zhao, Baoji Xu and Rejji Kuruvilla. Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. PNAS, January 9 2017. PDF

Jessica Houtz, Philip Borden, Alexis Ceasrine, Liliana Minichiello, and Rejji Kuruvilla. Neurotrophin signaling is required for glucose-induced insulin secretion. Developmental Cell. 2016 Nov 7;39(3):329-345. PDF

Naoya Yamashita and Rejji Kuruvilla. Neurotrophin signaling endosomes: biogenesis, regulation, and functions. Current Opinion in Neurobiology, 2016, 39: 139-145. PDF

Ami Patel, Naoya Yamashita, Maria Ascaño, Daniel Bodmer, Erica Boehm, Chantal Bodkin-Clarke, Yun Kyoung Ryu, and Rejji Kuruvilla. RCAN1 links impaired neurotrophin trafficking to aberrant development of the sympathetic nervous system in Down syndrome. Nature Communications, 2015, Dec 14;6:10119. PDF

Wang G, Rajpurohit SK, Delaspre F, Walker SL, White DT, Ceasrine A, Kuruvilla R, Li RJ, Shim JS, Liu JO, Parsons MJ, Mumm JS. First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass. 2015. Elife. Jul 28;4. PDF

Jessica Houtz and Rejji Kuruvilla. VIP pipes up: neuronal signals direct tubulogenesis. 2014. Dev Cell. Aug 25;30(4):361-2. PDF

Philip Borden, Jessica Houtz, Steven D. Leach, Rejji Kuruvilla. Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation. 2013. Cell Reports. July 25;4(2):287-301. PDF

Shih-Kuo Chen, Kylie S. Chew, David S. McNeill, Patrick W. Keeley, Jennifer L. Ecker, Buqing Q. Mao, Johan Pahlberg, Bright Kim, Sammy C.S. Lee, Michael Fox, William Guido, Kwoon Y. Wong, Alapakkam P. Sampath, Benjamin E. Reese, Rejji Kuruvilla,* and Samer Hattar*. Apoptosis regulates ipRGC spacing necessary for rods and cones to drive circadian photoentrainment. Neuron. 2013 Feb 6;77(3):503-15. *co-corresponding authors. PDF

Yun Kyoung Ryu, King Yu Lo, Sarah Collins, Haiqing Zhao* and Rejji Kuruvilla*. An autocrine Wnt5a-Ror signaling loop mediates sympathetic target innervation. Developmental Biology. 2013 Feb 27. *co-corresponding authors. PDF

Oscar Marcelo Lazo, Andres Gonzalez, Maria Ascano, Rejji Kuruvilla, Andres Couve, and Francisca Bronfman. BDNF regulates Rab11-mediated recycling endosome dynamics to induce dendritic branching. Journal of Neuroscience. 2013. J. Neuroscience. Apr 3;33(14):6112-22. PDF

Henry Ho, Michael Susman, Jay Bikoff, Yun Kyoung Ryu, Andrea Jonas, Linda Hu, Rejji Kuruvilla and Michael E. Greenberg. Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. PNAS. 2012 Mar 13;109(11):4044-51. Epub 2012 Feb 17. PDF

Maria Ascano, Daniel Bodmer and Rejji Kuruvilla. Endocytic trafficking of neurotrophins in neural development. Trends Cell Biol. 2012 Mar 21. PDF

Daniel Bodmer*, Maria Ascaño* and Rejji Kuruvilla, 2011. Isoform-specific dephosphorylation of dynamin1 by calcineurin couples neurotrophin receptor endocytosis to axonal growth. Neuron 70, 1085-1099. * Equal authors. PDF

Alissa Armstrong, Yun Kyoung Ryu, Deanna Chieco and Rejji Kuruvilla, 2011. Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development. J. Neuroscience, 31(7):2371–2381. PDF

Maria Ascaño, Alissa Richmond, Philip Borden, and Rejji Kuruvilla, 2009. Axonal Targeting of Trk Receptors via Transcytosis Regulates Sensitivity to Neurotrophin Responses. J. Neuroscience 29 (37):11674-11685. PDF

Daniel Bodmer, Seamus Levine-Wilkinson, Alissa Richmond, Sarah Hirsh and Rejji Kuruvilla, 2009. Wnt5a mediates NGF-dependent axonal branching and growth in developing sympathetic neurons. J. Neuroscience 29 (23):7569-7581. PDF

Larry S. Zweifel, Rejji Kuruvilla, and David D. Ginty, 2005. Functions and Mechanisms of Retrograde Neurotrophin Signaling. Nature Reviews Neuroscience 6, 615-625. PDF

Gregorio Valdez, Wendy Akmentin, Polyxeni Philippidou, Rejji Kuruvilla, David D. Ginty and Simon Halegoua, 2005. Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors. J. Neuroscience 25 (21), 5236-5247. PDF

Xi Chen, Haihong Ye, Rejji Kuruvilla, Narendrakumar Ramanan, Katherine W. Scangos, Chao Zhan, Nicolas M. Johnson1, Pamela M. England, Kevan M. Shokat and David D. Ginty, 2005. A chemical–genetic approach to studying neurotrophin signaling. Neuron 46, 13-21. PDF

Rejji Kuruvilla*, Larry Zweifel*, Natalia Glebova, Bonnie Lonze, Haihong Ye and David Ginty, 2004.  A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell 118, 1-20. * Equal authors. PDF

Haihong Ye*, Rejji Kuruvilla*, Larry Zweifel and David Ginty, 2003.  Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons. Neuron 39, 57-68. * Equal authors. PDF

Rejji Kuruvilla, Haihong Ye and David Ginty, 2000.  Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons. Neuron 27, 499-512. PDF